Central calcium-calimodulin-dependent blood pressure regulation

Central regulation of arterial blood pressure.

Central blood pressure under angiotensin and calcium channel blockade.

Hemodynamic studies have shown that, in healthy subjects, there is a gradual widening of the height of the pressure waveform as it travels from the central (aortic) elastic arteries to the peripheral muscular arteries (brachial artery)1 (Figure). This disparity, which tends to disappear in the presence of vascular disease/aging, does not require any additional energy input within the arterial s...

Peripheral and Central Effects of Melatonin on Blood Pressure Regulation

The pineal hormone, melatonin (N-acetyl-5-methoxytryptamine), shows potent receptor-dependent and -independent actions, which participate in blood pressure regulation. The antihypertensive effect of melatonin was demonstrated in experimental and clinical hypertension. Receptor-dependent effects are mediated predominantly through MT1 and MT2 G-protein coupled receptors. The pleiotropic receptor-...

Effect of Calcium Supplementation on Blood Pressure of Pregnant Women

The occurrence of pregnancy induced hypertension in low-income young nulliparous women is confirmed in different reports and increase the risk of preeclampsia. More knowledge on the role of nutrients especially calcium demonstrates its major role in regulating blood pressure. Sufficient intake of pregnancy can prevent pregnancy induced hypertension. This study was conducted to evaluate efficacy...

NO-dependent blood pressure regulation in RGS2-deficient mice.

The regulator of G protein signaling (RGS) 2, a GTPase-activating protein, is activated via the nitric oxide (NO)-cGMP pathway and thereby may influence blood pressure regulation. To test that notion, we measured mean arterial blood pressure (MAP) and heart rate (HR) with telemetry in N(omega)-nitro-l-arginine methyl ester (l-NAME, 5 mg l-NAME/10 ml tap water)-treated RGS2-deficient (RGS2(-/-))...